Glimepiride + Metformin is a powerful anti-diabetic medication used to effectively manage type 2 diabetes mellitus (T2DM). This combination helps control blood sugar levels, reduces insulin resistance, and enhances insulin production. It is widely prescribed to diabetic patients who do not achieve adequate glycemic control with diet and exercise alone.
How Glimepiride and Metformin Works
Glimepiride : A sulfonylurea that stimulates the pancreas to produce more insulin, helping lower blood sugar.
Metformin: A biguanide that reduces liver glucose production and enhances insulin sensitivity, making it easier for the body to utilize glucose efficiently.
By combining these two diabetes medications, patients experience better blood sugar control, reduced risk of complications, and improved overall health.
Indications
This combination is indicated for:
Type 2 diabetes management when diet and exercise alone are insufficient
Patients needing a dual-action approach to control blood sugar
Individuals with insulin resistance or metabolic syndrome
Note: This medication is NOT for type 1 diabetes or diabetic ketoacidosis patients.
Dosage & Administration
- The usual starting dose is one tablet per day, taken with meals to reduce the risk of gastrointestinal side effects.
- The dose may be adjusted based on blood sugar levels under a doctor’s supervision.
- Never exceed the prescribed dose to avoid hypoglycemia (low blood sugar).
Who Should Avoid This Medication?
Patients with kidney or liver disease
Pregnant or breastfeeding women (unless prescribed by a doctor)
Individuals with type 1 diabetes
People with a history of severe hypoglycemia
Possible Side Effects
Some patients may experience:
Mild nausea or diarrhea (usually temporary)
Dizziness or headache
Low blood sugar symptoms – shakiness, sweating, or confusion
Drug Interactions
Kindly be cautious when combining with:
- Alcohol (increases the risk of lactic acidosis)
- Beta-blockers (may mask hypoglycemia symptoms)
- Other diabetes medications (risk of excessive blood sugar reduction)
Note : Always Consult a physician before taking any medication, and do not rely solely on this information for medical advice.
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