Flupirtine Maleate 100 mg & Flupirtine 100 mg + Paracetamol 325 mg
Description
Flupirtine Maleate is a centrally acting non-opioid analgesic with muscle relaxant properties. It functions as a selective neuronal potassium channel opener (SNEPCO), providing analgesia by modulating pain pathways without causing opioid-like dependence. Flupirtine also exhibits NMDA receptor antagonist activity, contributing to its neuroprotective effects.
The combination of Flupirtine 100 mg + Paracetamol 325 mg enhances analgesic efficacy by combining the centrally acting analgesic properties of Flupirtine with the antipyretic and analgesic effects of Paracetamol. This combination is particularly beneficial for moderate to severe pain management.
Indications
- Acute and chronic pain conditions
- Musculoskeletal pain (e.g., back pain, cervical pain, fibromyalgia)
- Postoperative pain
- Neuropathic pain
- Osteoarthritis and rheumatoid arthritis
- Migraine and tension headaches
Dosage & Administration
Flupirtine Maleate 100 mg
- Adults: 100 mg orally, 2 to 3 times daily. Maximum dose: 400 mg per day.
- Duration: Should not be used for more than 2 weeks unless prescribed by a physician.
Flupirtine 100 mg + Paracetamol 325 mg
- Adults: 1 tablet orally, 2 to 3 times daily with or after food.
- Maximum dose: Not exceeding 3 tablets per day.
Dosage may vary based on the severity of pain and patient response. Always follow the physician’s prescription.
Precautions & Warnings
- Hepatic Impairment: Flupirtine is metabolized in the liver; avoid in patients with severe hepatic dysfunction.
- Renal Impairment: Use with caution in patients with kidney disorders.
- Prolonged Use: Not recommended for long-term therapy due to the risk of hepatotoxicity. Liver function tests should be monitored regularly.
- CNS Effects: May cause drowsiness, dizziness, and fatigue. Avoid activities requiring mental alertness (e.g., driving or operating machinery).
- Paracetamol Overdose Risk: Avoid exceeding the recommended dosage to prevent hepatotoxicity.
- Alcohol Interaction: Avoid alcohol consumption to prevent an increased risk of liver damage and CNS depression.
- Pregnancy & Lactation: Not recommended during pregnancy or breastfeeding unless clearly advised by a healthcare provider.
Advisory & Professional Guidance
- Prescription Only: Flupirtine and its combinations should only be used under medical supervision.
- Regular Monitoring: Liver enzyme levels should be assessed before and during treatment, especially in prolonged therapy.
- Contraindications: Avoid in patients with pre-existing liver disease, hypersensitivity to Flupirtine or Paracetamol, or a history of drug-induced liver injury.
- Drug Interactions: Caution with concurrent use of other hepatotoxic drugs, CNS depressants, and alcohol.
For further details and professional consultation, please contact a healthcare provider before initiating treatment.
*Note : Always Consult a physician before taking any medication, and do not rely solely on this information for medical advice. We do not hold responsibility of above mentioned information.