CLAVAGE® Amoxicillin & Clavulanic Acid
CLAVAGE® is a combination antibiotic formulation containing Amoxicillin, a broad-spectrum penicillin, and Clavulanic Acid, a beta-lactamase inhibitor. This combination extends Amoxicillin’s efficacy by protecting it from bacterial resistance, making it highly effective against a wide range of bacterial infections.
Composition & Their Functions
1. Amoxicillin (A Broad-Spectrum Penicillin Antibiotic)
- Mechanism of Action:
- Amoxicillin inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs), leading to bacterial death.
- Effective against Gram-positive and Gram-negative bacteria.
2. Clavulanic Acid (Beta-Lactamase Inhibitor)
- Mechanism of Action:
- Clavulanic Acid prevents bacterial resistance by inhibiting beta-lactamase enzymes, which are produced by resistant bacteria to neutralize penicillin antibiotics.
- This enhances Amoxicillin’s spectrum to cover beta-lactamase-producing pathogens.
Available Combinations & Their Uses
| Formulation | Composition | Indications |
|---|---|---|
| CLAVAGE® ES (D.S.) | Amoxicillin 600 mg + Clavulanic Acid 42.9 mg per 5 ml (60 ml) | Severe respiratory infections, pneumonia, complicated skin infections |
| CLAVAGE® Drops | Amoxicillin 80 mg + Clavulanic Acid 11.4 mg per ml (10 ml) | Pediatric bacterial infections (ear infections, throat infections, pneumonia) |
| CLAVAGE® 228.5 Tablet | Amoxicillin 200 mg + Clavulanic Acid 28.5 mg | Mild-to-moderate respiratory and urinary infections |
| CLAVAGE® 375 Tablet | Amoxicillin 250 mg + Clavulanic Acid 125 mg | Skin infections, dental infections, bacterial sinusitis |
| CLAVAGE® 457 D.S. | Amoxicillin 400 mg + Clavulanic Acid 57 mg per 5 ml (30 ml) | Pediatric respiratory infections, tonsillitis, bronchitis |
| CLAVAGE® 625 Tablet | Amoxicillin 500 mg + Clavulanic Acid 125 mg | Moderate bacterial infections, urinary tract infections (UTIs) |
| CLAVAGE® 625 LB Tablet | Amoxicillin 500 mg + Clavulanic Acid 125 mg + Lactic Acid Bacillus 60 million spores | Gastrointestinal infections, antibiotic-associated diarrhea |
| CLAVAGE® 1000 Tablet | Amoxicillin 875 mg + Clavulanic Acid 125 mg | Severe respiratory infections, complicated UTIs, bone infections |
| CLAVAGE® 300 Injection | Amoxicillin 250 mg + Clavulanic Acid 50 mg (Vial) | Moderate bacterial infections requiring IV therapy |
| CLAVAGE® 600 Injection | Amoxicillin 500 mg + Clavulanic Acid 100 mg (Vial) | Severe infections, sepsis, deep soft tissue infections |
| CLAVAGE® 1200 Injection | Amoxicillin 1000 mg + Clavulanic Acid 200 mg (Vial) | Hospital-acquired pneumonia, severe intra-abdominal infections |
Indications
CLAVAGE® is prescribed for bacterial infections caused by beta-lactamase-producing and non-beta-lactamase-producing organisms, including:
- Acute bacterial sinusitis
- Otitis media (ear infections)
- Community-acquired pneumonia (CAP)
- Acute exacerbation of chronic bronchitis
- Pharyngitis & tonsillitis
- Cystitis (bladder infection)
- Pyelonephritis (kidney infection)
- Cellulitis, impetigo, abscesses
- Infected wounds, surgical site infections
- Animal and human bite wounds
- Osteomyelitis (bone infection)
- Septic arthritis
- Pelvic inflammatory disease (PID)
- Septic abortion
- Peritonitis
- Severe dental abscesses with spreading cellulitis
Dosage & Administration
- Dosage varies based on age, weight, severity of infection, and renal function.
- Administered orally (tablets/suspensions) or via IV (injections).
- Take with food to reduce gastrointestinal discomfort and improve absorption.
- Suspensions should be shaken well before use.
General Dosage Guidelines
| Age Group | Dosage | Frequency |
|---|---|---|
| Adults & Adolescents (≥12 years) | 625 mg to 1000 mg | Twice daily |
| Children (6 months – 12 years) | 20-40 mg/day | Divided into 2 doses |
| Severe infections | 1000 mg IV every 8 hours | Hospital setting |
Precautions & Warnings
1. Contraindications
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-
- Known allergy to penicillins or cephalosporins.
- History of severe liver disease.
- Patients with mononucleosis (increased rash risk).
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2. Caution in Special Populations
-
-
- Renal Impairment: Dose adjustment required in kidney disease.
- Liver Dysfunction: Regular liver function monitoring advised.
- Pregnancy & Lactation: Generally safe, but should be used under medical supervision.
-
3. Drug Interactions
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- Reduces the effectiveness of oral contraceptives.
- Avoid use with probenecid (delays Amoxicillin excretion).
- May increase the risk of bleeding with warfarin (monitor INR levels).
Advisory & Patient Guidance
Complete Full Course: Do not stop the medication early, even if symptoms improve, to prevent antibiotic resistance.
Take With Food: Helps improve absorption and reduces gastrointestinal side effects.
Stay Hydrated: Helps prevent kidney-related issues.
Report Side Effects: Rash, diarrhea, or breathing difficulties require immediate medical attention.
Do Not Self-Medicate: Always use under a doctor’s supervision for appropriate dosing and duration.
CLAVAGE® is a highly effective combination antibiotic designed to treat a wide range of bacterial infections. The addition of Clavulanic Acid enhances the efficacy of Amoxicillin, making it a powerful choice for resistant infections. Whether in tablet, suspension, or injection form, CLAVAGE® provides optimal antibacterial coverage, rapid relief, and a high safety profile.
Note : Always Consult a physician before taking any medication, and do not rely solely on this information for medical advice.
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